Treatment for This Rare Skin Condition

Scleroderma is a skin and connective tissue condition characterized by thickening and hardening of the skin. This condition is rare and occurs more commonly in women and adults. Symptoms include numbness in fingers, toes and face, joint stiffness, sores over joints, and puffy hands and feet. Blood vessels and internal organs may also be affected in some cases. Scleroderma occurs when collagen, a fibrous protein which comprises the connective tissues, is overproduced in the body, and therefore overaccumulates.

While there is no cure for scleroderma, medications are available to help alleviate symptoms and prevent further complications. For a localized condition, topical treatments, such as moisturizers or steroids may be prescribed to apply to the affected area. Medications which dilate blood vessels and improve circulation may also be prescribed. These include calcium channel blockers, such as Norvasc. Creams containing nitroglycerin also may improve circulation. Nonsteroidal anti-inflammatory drugs may be given along with disease-modifying antirrheumatic drugs such as hydroxychloroquine (Plaquenil), penicillamine (Cuprimine, Depen), and methotrexate (Rheumatrex, Trexall). Immunosuppressants, such as cyclophosphamide (Cytoxan), may be used.