Reye’s Syndrome Linked to Aspirin

Reye’s syndrome is a rare condition that is linked to the use of aspirin use in children. The condition is serious and may affect the blood, liver, and brain. Children and teenagers who are recovering from a viral infection and are treated with aspirin are at risk for developing this condition. When Reye’s syndrome occurs, the level of ammonia and acidity in the blood may increase while the level of sugar in the blood may decrease. Swelling of the liver and the brain may occur. Seizures may result, and eventual coma and death may occur. Symptoms of Reye’s syndrome may begin a week after a viral infection, such as from influenza or the chickenpox. Initial symptoms may include nausea and vomiting, abnormal lethargy, disoriented behavior, and a decrease in mental alertness. Reye’s syndrome occurs most commonly in children between the ages of 4 and 12 years.

Treatment may include intravenous fluids, such as glucose and electrolyte solutions. Insulin may be required in small amounts to help increase the metabolism of sugar. Steroids may be used to decrease brain swelling and inflammation. Diuretics, such as mannitol, are sometimes used to decrease swelling of the brain. If the condition becomes severe, a ventilator may be necessary to help the child breathe.