Antibiotics and Other Treatments for Cystic Fibrosis

     Cystic Fibrosis (CF) is an inherited condition in which normally thin secretions, such as mucus and saliva from the nose and throat, become abnormally thick. In turn, the thick secretions lead to blockage in such vital organs as the pancreas and lungs. Thickened secretions block pancreatic enzymes that are necessary for the digestion of fats and proteins, as well as prevent the body from absorbing essential vitamins. In children and young adults, signs and symptoms of CF include coughing, wheezing, frequent chest and sinus infections, and clubbing of the fingertips and toes. A defective gene affects a protein that is involved in the normal exchange of salt into and out of cells, which contributes to the thickening of secretions characteristic of this condition.

 

     Although there is no cure available for CF, treatments including antibiotics for lung infections are important for managing this condition. Dornase alfa (Pulmozyme) is an enzyme that works to breakdown DNA which is responsible for thickened mucus. Albuterol is a bronchodilator that works to keep bronchial tubes clear and open. This medication may be administered by an inhaler or a nebulizer. Children affected by CF also may use pain relievers, such as ibuprofen (Advil, Motrin), to potentially slow lung deterioration.