One Cause of Leg Muscle Pain

Reduced blood flow to the legs may be caused by a condition called peripheral arterial disease (PAD). More specifically, atherosclerosis, or narrowed arteries, is a common cause of PAD. The condition can also be caused by a musculoskeletal disorder, peripheral neuropathy, or deep venous thrombosis (DVT). Peripheral arterial disease occurs more commonly after the age of 40. The risk of developing atherosclerosis is increased with smoking, diabetes, high blood pressure, and high cholesterol. Symptoms of PAD include muscle pain, however many persons with the condition may not experience any symptoms. Pain can occur in the hips, legs, and feet.  Symptoms typically become worse with exercise and improve with rest. In severe cases, gangrene, amputation, and death can result.

Persons who smoke should make efforts to quit. Exercise is also usually recommended. Antiplatelet medications, such as aspirin, clopidogrel (Plavix), and ticlopidine (Ticlid), may be used for the treatment of PAD. Aspirin also has a beneficial effect in prevention of heart attacks. Cilostazol (Pletal) may be prescribed. This medication works by suppressing platelet aggregation and through dilation of arteries. Pentoxifylline (Trental) works to improve blood flow. However, it is not considered the first treatment of choice.