When uric acid level is high, a condition called gout may develop. However, it is possible to have a high uric acid level (known as hyperuricemia) without any symptoms. Gout is characterized by pain in the joints. Persons affected by gout may develop kidney stones as a result of uric acid in the kidney; however kidney stones can also occur in persons who do not have gout. High blood pressure, obesity, and consuming large amounts of meat and seafood can increase the chances of developing gout. Pain and inflammation in the joints occur because the body’s immune system is reacting to the excess uric acid.
Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil) and indomethacin (Indocin), reduce joint swelling associated with a gout attack. Colchicine (Colcrys) works to decrease deposits of urate crystals in the joints, and the associated pain and inflammation. Glucocorticoids, such as prednisone and prednisolone (Orapred), are steroids that also have anti-inflammatory effects and may be prescribed. Probenecid may be prescribed to prevent future gout attacks. This medication works to increase excretion of uric acid. Allopurinol (Zyloprim) is a xanthine oxidase inhibitor, which works to prevent uric acid formation.
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